Abstract Search

ea0022p653 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Leptin receptor gene expression and its promoter methylation do not change with age in peripheral blood mononuclear cells

Roszkowska-Gancarz Malgorzata , Owczarz Magdalena , Polosak Jacek , Kurylowicz Alina , Puzianowska-Kuznicka Monika

Introduction: Leptin is a protein hormone secreted mainly by adipose tissue. It exerts its function via ubiquitously expressed receptors (LEPR). A number of LEPR isoforms are known. Metabolism of lipids and carbohydrates, that, in part, depends on leptin, might deteriorate with age. Aging is associated with a decrease of the global methylation and with hypermethylation of some promoter-located CpG islands. Such hypermethylation results in transcription inhibition.<p class=...

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ea0035p1060 | Thyroid (non-cancer) | ECE2014

THRB expression is affected by miR-26a and miR-496, but age-associated decrease of the expression of this gene in human peripheral blood mononuclear cells is not dependent on these miRNAs

Pawlik-Pachucka Eliza , Budzinska Monika , Domaszewska-Szostek Anna , Owczarz Magdalena , Gewartowska Magdalena , Kurylowicz Alina , Puzianowska-Kuznicka Monika

Introduction: Decreased function of the thyroid axis during aging is associated with a better functional performance and longer survival. This phenomenon can be a result not only of a lower production of thyroid hormones including bioavailable triiodothyronine, but also of age-associated alterations regarding triiodothyronine receptors.Methods: Functional studies regarding interaction between the 3′UTR of TRβ1 mRNA and in silico-ident...

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Endocrine Abstracts

Leptin receptor gene expression and its promoter methylation do not change with age in peripheral blood mononuclear cells

THRB expression is affected by miR-26a and miR-496, but age-associated decrease of the expression of this gene in human peripheral blood mononuclear cells is not dependent on these miRNAs

BiosciAbstracts